Saturday, July 31, 2010

Orb genes and the McGravitas connection

Strap yourselves in (and significant others if they request it) it's going to be a bumpy ride.
If the randomly arranged and possibly artificially created series of events that we might call my memory, serves me correctly, it was the Good Herr Doktor Bimler who alerted us all to the orb phenomena which strikes at the root of our liberty etc etc. And I'm just sayin that you should leave other people's roots alone. This of course sparked the usual flurry of furry theories about the genesis of orbs, no I will not pull anyone's finger.
Of course we at Riddled Systematic Inquiries (RSI) were not put off by fol de rols. Mrs Miggin's Walnut and Raccoon sausage rolls were a different story, of course (it'll brush out, I'm sure). We, of course headed, Beagle like, to the heart of the matter. Flies, yes, drosophila to be precise, not the trouser flies although that did way lay the experiment for some time.. Harmless little laboratory sandwich fillers or generators of terror?
Full story here... Yes trouser wetting ellipsis's are called for.
The orb gene encodes an RNA recognition motif (RRM)-type RNA-binding protein that is a member of the cytoplasmic polyadenylation element binding protein (CPEB) family of translational regulators.
Of course, we didn't rest there, normally we rest under the Wellesley Street off-ramp (tell them The Boys sent you and take some cooking Sherry), and found out more shocking truths about Drosophila gene regulation until we heard about THE WISPY GENE!!! And found out that:
...be required to trigger the destabilization of maternal mRNAs during egg activation. SMG is the major regulator of this activity
SMG!!! A major regulator!!! Mr Mcgravitas has some 'splaining to do methinks. Destabilizing of maternal RNA sounds like eco terrorism to me. Orly Taitz will not look at you now that all is known!!!
Unless I'm wrong and the name of the Drosphila is Wispy? It says: Wispy, the Drosphila... and how the fuck does science work, really?

21 comments:

Smut Clyde said...

Wispy, the Drosphila

I'm pretty sure that was a kid's book by Colin Thomson.

Another Kiwi said...

PJ working on the trilogy?

J— said...

If only we could free the destabilization of maternal mRNAs during egg activation from all that unnecessary, stultifying regulation. Free markets, free destabilization, free minds.

mikey said...

Johnny was sad. He sat in the gutter, tears dripping on his baggy, oversize jeans. The jeans were huge, tied tightly around the waist with a length of electric cord, and rolled up at the cuffs into a great wad of lighter colored denim that trapped all manner of flora and fauna as Johnny walked. He sat in the gutter by the telephone pole, on orange and one half a brown crayon in his hands, a small magnifying glass stuffed haphazardly in his pocket.

She flew suddenly out of the filthy cuff of his jeans. "I'm Wispy", she said as she buzzed up toward his face. Johnny was startled, as he'd never had a flying insect introduce itself. "Um, hi Wispy", he sniffled, quickly wiping his nose backhanded, remembering his manners like granmaw always said to. "I'm Johnny".

"Why are you crying, Johnny?" Wispy asked as she flew up, critically examining his right ear canal. Johnny looked down. "I...I guess I'm just lonely", he said, as the tears started to flow again.

Wispy flew around to settle on his nose, careful of the sticky mucous just below. "I'm a Drosphila", Wispy said. "Do you know what that is?"

Johnny thought it sounded familiar, but as all little boys know, you get teased if you act like you're smart, so he just said "no".

"I'll tell you what it fucking well means, you little sobbing shit" Wispy snapped in an angry tone dripping with bitterness and hate. "It means I'll be dead before morning, and you'll still be sitting here in the gutter whining like the worthless little prick you are. For crissakes, kid, haven't you ever read Ayn Rand?"

Johnny's eyes opened wide. Here was something worth thinking about. "But then what should I do?" he asked, hopeful for the first time in days.

"I noticed you have a magnifying glass in your pants pocket" Wispy began.

"Um, yeah. I'm sorry. I stole it off grampaw's desk when he went in the hospital. I can put it back..."

"NO!" Wispy shouted, too loud. She took a little Drosphila breath and buzzed her wings. "No. You can hold it so it concentrates the sunlight. You can burn things. You can burn ANTS!!" she proclaimed triumphantly.

Johnny took the magnifying glass out of his pocket and began to learn, soon melting his crayons into a foul puddle of fecal colored wax. Wispy called from a few yards up the block "Over here, Johnny. Ants!"

mikey said...

Point of interest, probably unknown to such slackers who fear their own keyboards. But Blogger very often gives me a "414 Request - URI Too Large" followed by the error "Comment too large to process".

But if you ignore it and open the blog in a new tab, well, there's your comment in all it's ridiculous verbose glory.

Yay?

merc said...

...step gently away from the keyboard Mikey.

ckc (not kc) said...

...as long as it doesn't say "comment too trivial to process"

mikey said...

Oh!

Ok.

Sorry...

merc said...

As i have noted of myself...nothing is too trivial for the all loving all embracing goodness that is the interdoink.

preaers, oldtime snooty before time.

Smut Clyde said...

"414 Request - URI Too Large" followed by the error "Comment too large to process".

It's just trying to built up your ego, mikey.
"OMG I've never seen one that large before."

Smut Clyde said...

the Good Herr Doktor Bimler

Now people will think that there is also a bad Herr Doktor, which is so not true.

ifthethunderdontgetya™³²®© said...

Johnny looked at Dropsy, started laughing hysterically, when SUDDENLY!

Johnny gets a feeling he's surrounded by fruit flies...fruit flies...fruit flies
~

Smut Clyde said...

Patti Smith.
Album cover photograph.
I'll be in my bunk.

tigris said...

Now people will think that there is also a bad Herr Doktor, which is so not true.

There is, too: he looks just like you, but with a beard.

merc said...

What about Average Herr Doktor then? I wanna meet him and his horses laughing hysterically.

benis, so many thoughts...

tigris said...

Mutton chops.

Righteous Bubba said...

it was the Good Herr Doktor Bimler who alerted us all to the orb phenomena which strikes at the root of our liberty etc etc.

I claim large orbs.

And I therefore wish to logister a complaint.

merc said...

Righteous. (whispers/ there are snark blogs?).

Another Kiwi said...

Indeed it was the Bubba of Righteousness who first warned us against the insidious eaters of souls, that are orbish.
I stand, sit and fall amusingly corrected.
I believe that there may be blogs of snark, merc. Most of the jokesters here frequent the one called Sadly, No, wherein even I have tried to raise the tone, to no avail.

Smut Clyde said...

I believe that Substance receives due credit for his pioneering orb-related activities in the next thread. However, we can't credit him for the minatory comments from that Righteous Bubba dude who doesn't seem to be around any more.

mikey said...

Gah!

Not even the harmless charm of the Orbs can make truthers palatable...

I agree with Captcha: schigogg